Antibacterial evaluation of some benzimidazole derivatives. Sample synthesis, characterization, experimental and. Here we are dedicated to developing a new machine learningbased predictor for the inhibition efficiency ie of benzimidazole derivatives. The corrosion inhibition was investigated by weight loss, electrochemical. Research article open access quantum chemical assessment of. A machine learningbased qsar model for benzimidazole derivatives as corrosion inhibitors by. Khaled chemistry department, rice university, 6100 main street, houston, tx 77005, usa. The synthesis some of 2alkylthio benzimidazole derivatives. Several experimental techniques have been used to study the corrosion. Benzimidazole, a key heterocycle in therapeutic chemistry, and its derivatives, are recently mentioned in the literature as corrosion inhibitors for steels cs, ms, pure metals fe, al, cu, zn and alloys. Benzimidazole derivatives as kinase inhibitors bentham science. The inhibition of benzimidazole derivatives on corrosion of iron in 1 m hcl solutions. Quantum chemical assessment of benzimidazole derivatives as corrosion inhibitors. Benzimidazoles heterocyclic building blocks sigmaaldrich.
Pdf corrosion inhibition efficiency of benzimidazole and. In this study, as part of our continued efforts to develop a selective jak1 inhibitor, a series of 1,2disubstituted benzimidazole 5carboxamide derivatives was prepared and their inhibitory activities against all four jak isozymes were evaluated. Other organic inhibitors such as benzimidazole and its derivatives have been reported in the literature as effective corrosion inhibitors. Sep 15, 20 the corrosion inhibition characteristics of 2mercapto benzimidazole mbi, 2mercapto benzimidazolylethyl acetate mbea, 2hydroxy benzimidazole hbi and 2hydroxy 5nitro benzimidazole hnbi on zinc corrosion in 0. The results showed that the inhibition efficiency increases with increasing the inhibitor. Six benzimidazole derivatives were investigated as corrosion inhibitors on mild steel in 1 m hydrochloric acid hcl using gravimetric and polarization techniques. This paper is aimed to determine the inhibition efficiency of benzimidazole derivatives via mild steel corrosion. Corrosion current density is increased by increasing the temperature, but, the rate of its increase is lower at the presence of benzimidazole and its derivatives. It is known that among these inhibitors, organic compounds containing one or more heteroatoms in their molecules such as thiazoles, benzotriazoles, imidazoles, benzimidazole derivatives are most effective 47. Using potentiodynamic polarization curves and electrochemical impedance spectroscopy eis, the inhibition ability of benzimidazole bi. Investigation of the adsorption characteristics of some selected sulphonamide derivatives as corrosion inhibitors at mild steelhydrochloric acid interface.
The corrosion inhibition behaviour of two new benzimidazole derivatives namely 22bromophenyl1h benzimidazole bpba and 22bromophenylh benzimidazole bpma on carbon stee cs in 0. Benzimidazole derivatives as copper alloy corrosion inhibitors article pdf available in croatica chemica acta 914. Triazole, benzotriazole and naphthotriazole as corrosion. Recent advances in the use of benzimidazoles as corrosion inhibitors. Antiinflammatory, proton pump inhibitor and synthesis of. The corrosion rate is reduce by adsorption organic inhibitors on the surface of the metal through. These compounds can adsorb onto the metal surface and block active surface sites, reducing the rate of corrosion. Ebensoan electrochemical and theoretical evaluation of new quinoline derivative as a corrosion inhibitor for carbon steel in hcl solutions. Corrosion inhibition efficiency of benzimidazole and benzimidazole derivatives for zinc, copper and brass. The inhibition of benzimidazole derivatives on corrosion of. Benzimidazole derivatives as copper alloy corrosion inhibitors. The inhibition performance of four benzimidazoles derivatives as corrosion inhibitors in hcl mild steel corrosions 22, including 2mercaptobenzimidazole, 2 amidobenzimidazole, 2methylbenzimidazole, and benzimidazole. Moreover, if a kinase becomes drugresistant, a multitargeted drug can act on the other kinases.
Theoretical study of the substituent effect on corrosion inhibition performance of benzimidazole and its derivatives. Benzimidazole, corrosion inhibitor, hologram quantitative structureactivity relationship, molecular design. The synthesized compounds were fully characterized, and their structures were elucidated based on elemental analysis, spectral data, and alternative synthetic pathways, whenever possible. The introduction of two new benzimidazole derivatives, 2. Research article open access quantum chemical assessment of benzimidazole derivatives as corrosion inhibitors hasan r obayes1, ghadah h alwan2, abdul hameed mj alobaidy3, ahmed a alamiery3,4,abdulamirhkadhum4. Pdf ecofriendly chalcones derivatives as corrosion. The majority of wellknown inhibitors are organic compounds containing multiple bonds and heteroatoms, such as o, n or s, which allow adsorption onto the metal surface. Theoretical study of benzimidazole and its derivatives and. Twenty benzimidazoles bi derivatives as potential steel corrosion inhibitors were collected from the literature 11,2123 which was used for this present study. Corrosion inhibitors are substances that protect metals against corrosion by. The inhibition of benzimidazole derivatives on corrosion of iron in 1 m hcl solutions k.
Studies of iron corrosion inhibition using chemical. In our previous publication, three novel benzimidazole derivatives, namely 2aminomethyl benzimidazole abi, bis2benzimidazolylmethyl amine bbia and tri2benzimidazolylmethyl amine tbia, have been reported as effective inhibitors for corrosion of mild steel in acidic media. Computational simulation of the molecular structure of. Experimental and quantum chemical studies on two triazole derivatives as corrosion inhibitors for mild steel in acid media. Pdf quantum chemical assessment of benzimidazole derivatives. Apr 15, 20 investigation of the adsorption characteristics of some selected sulphonamide derivatives as corrosion inhibitors at mild steelhydrochloric acid interface. Protection of metallic surfaces can be achieved by the addition of specific compounds known as corrosion inhibitors. Development of a predictive model for corrosion inhibition.
Jak inhibition thus modulates cytokinemediated effects. Benzimidazole, b3lyp, corrosion, dft, inhibitor introduction corrosion is an electrochemical process by which metallic structures are destroyed gradually through anodic dissolution 1. Moreover, many nheterocyclic compounds have been proved to be effective inhibitors for metals and alloys corrosion in aqueous media 9. Pdf synthesis of some benzimidazolebased heterocycles. Electrochemical and weight loss experiments were used to elucidate the corrosion inhibition potentials of bpba and bpma. Other organic inhibitors such as benzimidazole and its derivatives have been reported in the literature as effective corrosion inhibitors with structural features that allow adsorption to the metal surface 26 27. Pdf seawater is a corrosive medium that adversely affects on the metallic structures. Comparative studies on the electrochemical and physicochemical. This work provides valuable information for further research and design of more promising corrosion inhibitors in the oil and gas field. Surface protection of mild steel using benzimidazole derivatives. The present method is used to inhibit corrosion of a metal surface in contact with an aqueous system using 2substituted imidazoles and 2substituted benzimidazoles, and provides enhanced protection against corrosion of metals in the aqueous system.
For this investigation, the corrosion inhibition efficiencies of the protonated and nonprotonated spesies of benzimidazole. Benzimidazole derivatives as potent jak1selective inhibitors. The phenomenon of inhibiting corrosion of carbon steel using organic inhibitors imidazole and benzimidazole derivatives was investigated and quantified by electrochemical impedance. Some benzimidazole derivatives are multitarget inhibitors. Benzimidazole derivatives as bromodomain inhibitors gilead.
In view of its excellent behaviour as efficient corrosion inhibitors, the present work intended to synthesize three benzimidazole derivatives and investigate their efficiency as corrosion inhibitors for mild steel in 0. It is noted that all compounds are a good corrosion inhibitor for mild steel in acidic media. Theoretical study of the substituent effect on corrosion. Some derivatives of benzimidazole are excellent corrosion inhibitors for metals and alloys in acidic solution. Benzimidazole structure is the nucleus in some drugs such as proton pump inhibitors and anthelmintic agents. Antiinflammatory, proton pump inhibitor and synthesis of some new benzimidazole derivatives rezk r ayyad1,5, helmi m sakr1, kamal m elgamal2,4, ibrahim h eissa1, ahmad ha tita1, adel s abd elraheim1, farag f sherbini2 and ahmad m mansour3 1pharmaceutical chemistry department, faculty of pharmacy boys, alazhar university, cairo, egypt. Examples of benzimidazole class fungicides include benomyl, carbendazim, chlorfenazole, cypendazole, debacarb, fuberidazole, furophanate, mecarbinzid, rabenzazole, thiabendazole, thiophanate. Recent advances in the use of benzimidazoles as corrosion. Benzimidazole derivatives are well known because of their nontoxicity and good. Results obtained from weight loss, dc polarization and ac impedance measurements are in reasonably good agreement and show increased inhibitor ef. Quantum chemical assessment of benzimidazole derivatives as.
Prediction of inhibition performance of some benzimidazole. The properties most relevant to their potential action as corrosion inhibitors. Benzimidazole, a key heterocycle in therapeutic chemistry, and its derivatives, are recently mentioned in the literature as corrosion inhibitors for steels cs, ms, pure metals fe. Imidazole derivatives as corrosion inhibitors for zinc in. Benzimidazole derivatives as corrosion inhibitors for zinc in acid. The compounds of formulae i and ii were prepared as disclosed in example 1. First, a comprehensively numerical representation was. Corrosion inhibition for carbon steel of benzimidazole derivatives synthesized in sulfuric acid solution. The benzimidazole derivatives effect on mild steel corrosion in 1 m hcl solution was studied using weight loss measurement after 24 h of immersion. Disclosed are methods of using nitrogencontaining compounds as corrosion inhibitors. Muhammad taha, nor hadiani ismail, syahrul imran, manikandan selvaraj, hesham rashwan, fatin ummi farhanah, fazal rahim, krishnan selvarajan kesavanarayanan, muhammad ali. Benzimidazole derivatives as corrosion inhibitors for zinc.
Obayes hr, alwan gh, alobaidy ah, alamiery aa1, kadhum aa, mohamad ab. They protect mild steel against corrosion by adsorbing on the metal surface with an inhibition rank of tbia. Quantum chemical assessment of benzimidazole derivatives as corrosion inhibitors article pdf available in chemistry central journal 81. Comparative inhibition study of mild steel corrosion in. In the present era, the challenge given by corrosion can be easily mitigated using organic compounds as corrosion inhibitor in different corrosive media. The inhibition efficiency increased with increase in inhibitor. Touhamicorrosion inhibition of ordinary steel in 5. Copper corrosion inhibition in 1 m hno3 by two benzimidazole.
Experimental and quantum chemical studies on the corrosion. Zincii chloride was reacted with some 1benzylbenzimidazole. Organic compounds containing n, s atoms and functional group prepared for used as corrosion inhibitors. Benzimidazole derivatives are adsorptive inhibitors and their adsorption obeys the langmuirs adsorption isotherm. The inhibition efficiency increased with increase in inhibitor concentration. Benzimidazole derivatives act as mixed type inhibitors, exhibiting stronger inhibitive effect on the cathodic reaction than on the anodic one.
The corrosion inhibition characteristics of 2mercapto benzimidazole mbi, 2 mercapto benzimidazolylethyl acetate mbea, 2hydroxy. A comparative theoretical study of three benzimidazole isomers, benzimidazole. Synthesis of some benzimidazole based heterocycles and their application as copper corrosion inhibitors. Hqsar study and molecular design of benzimidazole derivatives. Benzimidazole, a heterocyclic aromatic organic compound consisting of a fusion of benzene and imidazole, in an extension of the wellelaborated imidazole system, has been used as a carbon skeleton for n heterocyclic carbenes, usually used as ligand for transition metal complexes. Notably, it is a referred, highly indexed, online international journal with high. In the present work a quantitative structure activity relationships qsar of 15 as corrosion inhibitors.
Electrochemical investigation of corrosion on aisi 316. A machine learningbased qsar model for benzimidazole. The substituent effects of electrondonating and withdrawing on the efficiency of corrosion inhibition of benzimidazole and its derivatives have been studied by density functional theory dft and mollerplesset perturbation theory mp2 calculations at aqueous medium. Experimental and computational studies on the inhibition. Benzimidazole nucleosides, nucleotides, and related. Corrosion mitigation by planar benzimidazole derivatives. Among these, benzimidazole and its derivatives intensively were investigated as effective corrosion inhibitors in various acid solutions 1923.
Hqsar study and molecular design of benzimidazole derivatives as corrosion inhibitors sun sangdun 1, mi siqi 2, you jing 3, yu jiliang 3, hu songqing 2, liu xinyong 4 1 oil production technology. The experimental performance of these molecules was evaluated by. Experimental and theoretical evaluation of two benzimidazole. The corrosion has a considerable amount of impact on the economics of every nation, and ultimately it affects the gdp. Corrosion behavior of copper in 1 m nitric acid containing either 2mercaptobenzimidazole mbi or 2thiomethylbenzimidazole tmbi was investigated experimentally and theoretically via weight loss method and quantum chemical approaches. Corrosion inhibition for carbon steel of benzimidazole. The inhibition of benzimidazole derivatives on corrosion. Evaluation of 2mercaptobenzimidazole derivatives as corrosion. Antibacterial evaluation of some benzimidazole derivatives and their zincii complexes s. Dec 01, 2016 in addition, the corrosion rate of copper in the presence of known corrosion inhibitors benzimidazole, 2phenylbenzimidazole, and tolyltriazole was determined using linear polarization resistance measurements. They have shown that the presence of halogens in the inhibitor. The inhibiting effect of some chalcones derivatives on the corrosion of carbon steel in 1 m hcl was studied by weight loss, potentiodynamic polarization, electrochemical impedance spectroscopy eis and electrochemical frequency modulation efm techniques. Generally, results showed that the corrosion inhibition efficiency of the investigated molecules was. The corrosion inhibition characteristics of 2mercapto benzimidazole mbi, 2mercapto benzimidazolylethyl acetate mbea, 2hydroxy benzimidazole hbi and 2hydroxy 5nitro benzimidazole hnbi on zinc corrosion in 0.
Quantum chemical assessment of benzimidazole derivatives. The corrosion inhibition characteristics of 2mercapto benzimidazole mbi, 2mercapto benzimidazolylethyl acetate mbea, 2hydroxy. Inhibition efficiencies were found to follow the order. Experimental and computational studies on the inhibition performances of benzimidazole and its derivatives for the corrosion of copper in nitric acid. The janus kinase jak family comprises four members jak1, jak2, jak3, and tyk2 that play a key role in mediating cytokine receptor signaling. The corrosion inhibition performances of four imidazoliumbased corrosion inhibitors on mild steel in acidic medium, namely benzimidazole bi, 2aminobenzimidazole abi, 2phenylbenzimidazole pbi. This process can be carried out after protection of n on the benzimidazole with. International journal of industrial chemistry, feb 2016. Corrosion inhibition efficiency of these heterocyclic compounds is explained by the. Pdf benzimidazole derivatives as copper alloy corrosion. The hydrogen atoms on the rings can be substituted by other groups or atoms. Pharmacological compounds of benzimidazole derivatives are potent inhibitors for a variety of enzymes.
New benzimidazole derivatives as corrosion inhibitors for. Corrosion inhibitorscorrelation between electronic. The inhibition efficiencies e exp % of the benzimidazole derivatives 15 were determined experimentally by electrochemical impedance spectroscopy eis. Deligeorgiev, influence of the molecular structure on the inhibitor properties of benzimidazole derivatives on mild steel corrosion in 1 m hydrochloric acid.
Us10202694b2 2substituted imidazole and benzimidazole. Introduction benzimidazole is a fused aromatic imidazole ring system where a benzene ring is fused to the 4 and 5 positions of an imidazole ring. February 2019 benzimidazole derivatives as corrosion inhibitors 383 journal of heterocyclic chemistry doi 10. Pdf the majority of wellknown inhibitors are organic compounds containing multiple bonds.
Computational prediction of inhibition efficiency ie for inhibitor molecules is a crucial supplementary way to design novel molecules that can efficiently inhibit corrosion onto metallic surfaces. Inhibitor efficiency was found to depend on concentration and on the structure of the molecules. Benzimidazole derivatives as corrosion inhibitors for zinc in. The molecular behavior of some benzimidazole c 7 h 6 n 2 derivatives as corrosion inhibitors of iron in hydrochloric acid hcl solution was investigated quantum electrochemically via the inhibitors chemical potential.